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Patient Education Disclosure: Oral Terbinafine and Fluconazole

Last revised July 1, 2024 

Before initiating treatment with oral terbinafine or fluconazole, it's important to understand the risks and benefits associated with these medications. Below, we outline the potential benefits as well as the possible risks involved:

Benefits

1. Effective Treatment: Both oral terbinafine or fluconazole are commonly prescribed medications for fungal infections, including toenail fungus (onychomycosis) and yeast infections.

2. Convenience: Oral medications offer a convenient treatment option compared to topical treatments, as they are taken orally and do not require frequent application.

3. Comprehensive Treatment: The combination of oral terbinafine or fluconazole along with a topical prescription such as ciclopirox or terbinafine provides a comprehensive approach to fungal infections, targeting the infection from different angles to enhance effectiveness.

4. Systemic Action: Oral medications work systemically, meaning they circulate throughout the body to reach the site of infection, potentially providing more thorough treatment compared to topical medications.

Risks

1. Side Effects: Like all medications, oral terbinafine and fluconazole may cause side effects. Common side effects include gastrointestinal upset, headache, and skin rash. Less common but more severe side effects may include liver toxicity, allergic reactions, and changes in taste sensation.

2. Drug Interactions: Both medications have the potential to interact with other medications you may be taking. It's essential to inform your healthcare provider of all medications, supplements, and herbal products you are currently using to prevent harmful interactions.

3. Liver Function Monitoring: Oral terbinafine and fluconazole can affect liver function. Depending on several factors, your healthcare provider may recommend periodic liver function tests to monitor for any signs of liver damage during treatment.

4. Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it's essential to discuss the risks and benefits of oral terbinafine and fluconazole with your healthcare provider. These medications may pose risks to the developing fetus or infant.

5. Resistant Infections: In some cases, fungal infections may become resistant to treatment with oral medications. Your healthcare provider will monitor your response to treatment and may adjust your medication regimen if necessary.


Conclusion

Before starting treatment with oral terbinafine or fluconazole, it's essential to weigh the potential benefits against the risks and discuss any concerns with your healthcare provider. By understanding the risks and benefits of these medications, you can make informed decisions about your treatment plan.

If you have any questions or require further clarification, please don't hesitate to reach out to your healthcare provider.

Other Drug Information

Some of the medications you may be prescribed are compounded in a US-licensed compound pharmacy and not FDA approved for treatment of toenail fungus.