"The right toe was treated for 20 days with STRIDE™, while the left toe was not. The difference is dramatic. It's incredible to see such visible improvement in such a short period."
Dr. Peter J. Bregman
Podiatrist
STRIDE solo™: Topical-Only Approach
For those who prefer not to take oral medication, we offer STRIDE Clearnail Renewal™ topical solution as a standalone treatment. It’s a powerful option that delivers visible results within days, providing an effective and convenient solution for toenail fungus without the need for systemic medications.
Ready To Cure Toenail Fungus For Good?
"I have literally tried everything over the years. Nothing worked until now. STRIDE™ is the real deal."
- Jeff S.
Ready To Cure Toenail Fungus For Good?
"I have literally tried everything over the years. Nothing worked until now. STRIDE is the real deal."
Bethany Mulhanney
The role of Fluconazole in STRIDE's toenail fungus treatment
Fluconazole serves as an important alternative in the arsenal against toenail fungus, particularly when Terbinafine is not suitable due to medical contraindications or patient preference. Here are several reasons why Fluconazole is chosen as an alternative oral treatment:
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The role of Fluconazole
Broad-Spectrum Antifungal
Fluconazole belongs to the azole class of antifungals, which are known for their broad-spectrum activity. It works by inhibiting the enzyme lanosterol 14α-demethylase, which is involved in the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased membrane permeability and eventual fungal cell death. While it is effective against a wide variety of fungi, it is particularly useful against yeast infections and certain molds, which might coexist with or mimic toenail fungus infections.
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The role of Fluconazole
Favorable Dosage Schedule
Fluconazole is often appreciated for its convenient dosing regimen. Unlike some other antifungals that require daily administration, Fluconazole can be prescribed in a once-weekly dosage, which can improve patient compliance and convenience, especially in long-term treatments necessary for clearing nail fungus.
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The role of Fluconazole
Alternative for Sensitive Patients
Patients who experience or are at risk of severe side effects from Terbinafine, such as those with liver issues or who have had adverse reactions to allylamine antifungals, may find Fluconazole a safer alternative. Its different mechanism and metabolic pathway mean it often presents a different side effect profile.
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The role of Fluconazole
Effective Against Resistant Strains
In cases where fungal strains have developed resistance to other treatments, Fluconazole may still prove effective. This makes it a valuable option for treating difficult cases where first-line treatments have failed.
Targeted and Enhanced Penetration
- Direct Application: The topical solution is applied directly to the affected area, allowing for targeted action against the fungus on and under the nail. This local application helps in addressing the fungus right at the source.
- Enhanced Penetration: Ingredients like Ascorbyl glucoside and Lactic acid in the STRIDE ClearNail Renewal™ formulation are not just antifungal; they help loosen the hard structure of the nail, allowing the active antifungal component, Terbinafine, to penetrate more deeply into the nail bed where the fungus thrives.
The science works or get your money back!
Now that you understand the STRIDE™ science, let's take that step towards beautiful feet.
Each option is supported by scientific understanding and clinical research, ensuring that you receive a treatment that not only addresses the fungal infection but also suits your personal health profile and preferences.
"When I started seeing visibly better toenails after about a week, I started to get really excited."
Samantha B.
Anchorage, AK