The STRIDE™ Science that Beats Toenail Fungus
STRIDE™ has shown a high success rate, with clinical trials reporting an 89% effectiveness in treating toenail fungus.
Get Treated by a Doctor Now →
As Seen In
Two Approaches Rooted in Science
Depending on your preferences and specific circumstances, your physician will prescribe the best option for you.
Two-Medication Combo
The treatment combines an oral antifungal, like terbinafine or fluconazole, with STRIDE Clearnail Renewal™ topical solution. Oral medications work from within to disrupt fungal growth, while STRIDE Clearnail Renewal™ targets the infection directly, producing clearer nails in just a few days.
Topical-Only Approach
For those who prefer not to take oral medication, we offer STRIDE Clearnail Renewal™ topical solution as a standalone treatment. It delivers visible results within days — effective and convenient, without systemic medications.
What to Expect During Treatment
Treatment begins
STRIDE starts working internally and externally to fight the infection. Subtle improvement in appearance.
Visible changes
Reduced discoloration, smoother nail texture, slowed or stopped spreading.
Healthy nail growth
New, clear nail begins to replace the damaged one.
3–12 months
Continued use is necessary to maintain clear nails and prevent recurrence.
The Role of Terbinafine
Terbinafine is the primary oral antifungal in STRIDE's DUO protocol, chosen for its potency, safety profile, and nail penetration.
Potent Antifungal Action
Terbinafine is an allylamine antifungal that targets squalene epoxidase — a key enzyme in fungal cell membrane biosynthesis. By inhibiting this enzyme, it causes ergosterol deficiency and squalene accumulation, leading to fungal cell death. Especially effective against dermatophytes, the most common cause of nail infections.
High Cure Rates
Clinical studies have consistently shown cure rates with Terbinafine often exceeding 70–90% effectiveness, depending on treatment duration and infection severity. This high efficacy makes it a primary component of STRIDE's protocol.
Favorable Pharmacokinetics
Terbinafine is well-absorbed orally and penetrates deeply into nails and skin, remaining active for extended periods even after treatment ends. This reduces total therapy duration needed to clear the infection.
Low Resistance Rates
Compared to other antifungals, fungi develop resistance to Terbinafine less frequently — making it a reliable, durable choice, especially in areas where fungal infections are prevalent.
The Role of Fluconazole
Fluconazole serves as an important alternative, particularly when Terbinafine is not suitable due to medical contraindications or patient preference.
Broad-Spectrum Antifungal
Fluconazole (azole class) inhibits lanosterol 14α-demethylase, disrupting ergosterol synthesis and increasing fungal cell membrane permeability. Effective against a wide range of fungi including yeasts and certain molds.
Favorable Dosage Schedule
Unlike medications requiring daily dosing, Fluconazole can be prescribed once-weekly — improving patient compliance and convenience for long-term treatment.
Alternative for Sensitive Patients
For patients at risk of side effects from Terbinafine — such as those with liver concerns — Fluconazole offers a different metabolic pathway and side effect profile.
Effective Against Resistant Strains
In cases where fungal strains have developed resistance to first-line treatments, Fluconazole may still prove effective, making it a valuable option for difficult cases.
How STRIDE ClearNail Renewal™ Works
Fluconazole serves as an important alternative, particularly when Terbinafine is not suitable due to medical contraindications or patient preference.
Targeted & Enhanced Penetration
Ascorbyl glucoside and Lactic acid loosen the nail structure, allowing Terbinafine to penetrate deeper into the nail bed where the fungus thrives.
Accelerates Nail Recovery
A multi-faceted approach reduces the likelihood of resistance. Visible results improve patient motivation and adherence — a virtuous cycle.
Synergistic Effect
Oral treatment works systemically from inside; topical acts externally. Continuous protection against reinfection and superior cure rates.
"The right toe was treated for 20 days with STRIDE™, while the left toe was not. The difference is dramatic. It's incredible to see such visible improvement in such a short period."
Dr. Peter J. Bregman
Podiatrist
Ready to Start?
Two treatment options — both doctor-prescribed and pharmacy-dispensed.
STRIDE DUO™
Oral + topical combination. 89% clinical effectiveness.
From $210 / 3 months
STRIDE SOLO™
ClearNail Renewal™ topical-only. No systemic absorption.
From $195 / 3 months
"I have literally tried everything over the years. Nothing worked until now. STRIDE™ is the real deal."
— Jeff S., Verified Buyer
Get Treated by a Doctor Now →HSA & FSA Eligible · Money-Back Guarantee · Doctor Prescribed
